Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes
journal contributionposted on 02.12.2021, 11:33 by Nicola J Farrer, Darren GriffithDarren Griffith
Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide–alkyne cycloaddition–based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechanisms of action and resistance of Pt-based drugs is also being revealed through click-based detection, isolation and tracking of Pt drug surrogates in biological and cellular environments. Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation.
Wellcome Trust (201406/Z/16/Z)
Cancer Research UK (C5255/A18085) through the Cancer Research UK Oxford Centre,
Singapore Chemical Group (Innovation Fund Young Researcher Award)
Synthesis and Solid State Pharmaceutical Centre (SSPC)
Science Foundation Ireland (SFI)
European Regional Development Fund under Grant Number 12/RC/ 2275_P2
L‘Oreal (Women in Science Fellowship)
CommentsThe original article is available at https://www.sciencedirect.com
Published CitationFarrer NJ, Griffith DM. Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes. Curr Opin Chem Biol. 2020;55:59-68.
Publication Date13 January 2020
- Chemistry and Pharmaceutical Sciences
- Published Version (Version of Record)
CopperGoldPlatinumAzidesAlkynesOrganometallic CompoundsTriazolesAntineoplastic AgentsFluorescent DyesLigandsMolecular StructureDrug ResistanceClick ChemistryCellular MicroenvironmentCycloaddition ReactionDrug DevelopmentAlkyneAnalyseAnticancerAzideCuAACCycloadditionFunctionaliseSPAACSynthesisTargetTrackTriazoleiClickOrganic ChemistryMedicinal and Biomolecular ChemistryBiochemistry and Cell Biology