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Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes

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journal contribution
posted on 02.12.2021, 11:33 by Nicola J Farrer, Darren GriffithDarren Griffith
Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide–alkyne cycloaddition–based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechanisms of action and resistance of Pt-based drugs is also being revealed through click-based detection, isolation and tracking of Pt drug surrogates in biological and cellular environments. Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation.

Funding

Wellcome Trust (201406/Z/16/Z)

Cancer Research UK (C5255/A18085) through the Cancer Research UK Oxford Centre,

Singapore Chemical Group (Innovation Fund Young Researcher Award)

Synthesis and Solid State Pharmaceutical Centre (SSPC)

Science Foundation Ireland (SFI)

European Regional Development Fund under Grant Number 12/RC/ 2275_P2

L‘Oreal (Women in Science Fellowship)

History

Comments

The original article is available at https://www.sciencedirect.com

Published Citation

Farrer NJ, Griffith DM. Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes. Curr Opin Chem Biol. 2020;55:59-68.

Publication Date

13 January 2020

PubMed ID

31945705

Department/Unit

  • Chemistry

Research Area

  • Cancer
  • Chemistry and Pharmaceutical Sciences

Publisher

Elsevier BV

Version

  • Published Version (Version of Record)