Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.
journal contributionposted on 2022-03-31, 08:46 authored by Daniela Babovic, Colm M. O'Tuathaigh, Gerard J. O'Sullivan, Jeremiah J. Clifford, Orna TigheOrna Tighe, David T. Croke, Maria Karayiorgou, Joseph A. Gogos, David CotterDavid Cotter, John WaddingtonJohn Waddington
Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.
CommentsThis article is available at http://www.sciencedirect.com/science/journal/01664328.
Published CitationBabovic D, O'Tuathaigh CM, O'Sullivan GJ, Clifford JJ, Tighe O, Croke DT, Karayiorgou M, Gogos JA, Cotter D, Waddington JL. Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behavioural Brain Research 2007;183(2):236-9.
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences