Royal College of Surgeons in Ireland
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Exploring the genetic overlap between psychiatric illness and epilepsy: a review.

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journal contribution
posted on 2021-01-26, 16:42 authored by Ciaran CampbellCiaran Campbell, Gianpiero CavalleriGianpiero Cavalleri, Norman DelantyNorman Delanty
There is a long-documented epidemiological link between epilepsy and psychiatric disorders. People with epilepsy are at an increased risk for a variety of psychiatric illnesses, as are their family members, and people with epilepsy may experience psychiatric side-effects due to their anti-epileptic drugs. In recent years, large-scale, collaborative international studies have begun to shed light on the role of genetic variation in both epilepsy and psychiatric illnesses, such as schizophrenia, depression, and anxiety. But so far, finding shared genetic links between epilepsy and psychiatric illness has proven surprisingly difficult. This review will discuss the prevalence of psychiatric comorbidities in epilepsy, recent advances in genetic research into both epilepsy and psychiatric illness, and the extent of our current knowledge of the genetic overlap between these two important neurobiological conditions.


Science Foundation Ireland (SFI) under Grant Number 16/RC/3948

European Regional Development Fund

FutureNeuro industry partners



The original article is available at

Published Citation

Campbell C, Cavalleri GL, Delanty N. Exploring the genetic overlap between psychiatric illness and epilepsy: a review. Epilepsy & Behavior. 2020;102:106669

Publication Date

27 November 2019

PubMed ID



  • FutureNeuro Centre
  • School of Pharmacy and Biomolecular Sciences
  • Beaumont Hospital




  • Accepted Version (Postprint)