Expression, regulation and function of Aquaporin-3 in colonic epithelial cells
journal contributionposted on 10.09.2021, 13:23 authored by Johathan Yde, Stephen KeelyStephen Keely, Hanne B. Moeller
The human colon balances water and electrolyte absorption and secretion while also forming a barrier protecting the body from the entry of harmful components. Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Although expression of colonic epithelial AQP3 is altered in several intestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, the regulation and specific roles of AQP3 remain to be fully defined. In this mini-review, we summarize the current understanding of the expression, regulation, and biological functions of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.
Science Foundation Ireland (SFI) | Grant ID: 16/IA/4445
Crohn's & Colitis Foundation of America - CCFA | Grant ID: 354322
Aage og Johanne Louis-Hansen Fonden
AUFF starting grant, Knud og Edith Eriksens Mindefond
A.P. Møller Fonden
Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis’ Legat
CommentsThe original article is available at https://www.sciencedirect.com/
Published CitationYde J, Keely SJ, Moeller HB. Expression, regulation and function of Aquaporin-3 in colonic epithelial cells. Biochim Biophys Acta Biomembr. 2021;1863(7):183619.
Publication Date31 March 2021
- Beaumont Hospital
- Molecular Medicine
- Immunity, Infection and Inflammation
- Accepted Version (Postprint)