Royal College of Surgeons in Ireland
Redlined_revised_manuscript_210317_final.docx (455.65 kB)
Download file

Expression, regulation and function of Aquaporin-3 in colonic epithelial cells

Download (455.65 kB)
journal contribution
posted on 2021-09-10, 13:23 authored by Johathan Yde, Stephen KeelyStephen Keely, Hanne B. Moeller
The human colon balances water and electrolyte absorption and secretion while also forming a barrier protecting the body from the entry of harmful components. Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Although expression of colonic epithelial AQP3 is altered in several intestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, the regulation and specific roles of AQP3 remain to be fully defined. In this mini-review, we summarize the current understanding of the expression, regulation, and biological functions of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.


Science Foundation Ireland (SFI) | Grant ID: 16/IA/4445

Crohn's & Colitis Foundation of America - CCFA | Grant ID: 354322

Aage og Johanne Louis-Hansen Fonden

AUFF starting grant, Knud og Edith Eriksens Mindefond

Carlsberg Fondet

A.P. Møller Fonden

Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis’ Legat

STIBO fonden



The original article is available at

Published Citation

Yde J, Keely SJ, Moeller HB. Expression, regulation and function of Aquaporin-3 in colonic epithelial cells. Biochim Biophys Acta Biomembr. 2021;1863(7):183619.

Publication Date

31 March 2021

PubMed ID



  • Beaumont Hospital
  • Molecular Medicine

Research Area

  • Immunity, Infection and Inflammation
  • Cancer


Elsevier BV


  • Accepted Version (Postprint)