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FK506-binding protein like (FKBPL) has an important role in heart failure with preserved ejection fraction pathogenesis with potential diagnostic utility

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journal contribution
posted on 2023-03-21, 08:11 authored by Michael Chhor, Hao Chen, Djurdja Jerotić, Milorad Tešić, Valentina N Nikolić, Milan Pavlović, Rada M Vučić, Benjamin Rayner, Chris J Watson, Mark Ledwidge, Kenneth McDonald, Tracy RobsonTracy Robson, Kristine C McGrath, Lana McClements

Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding the implementation of effective treatments. FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are critical mediators of angiogenesis and inflammation. Thus, in this study, we investigated-for the first time-FKBPL's role in the pathogenesis and as a biomarker of HFpEF. In vitro models of cardiac hypertrophy following exposure to a hypertensive stimulus, angiotensin-II (Ang-II, 100 nM), and/or AD-01 (100 nM), for 24 and 48 h were employed as well as human plasma samples from people with different forms of HFpEF and controls. Whilst the FKBPL peptide mimetic, AD-01, induced cardiomyocyte hypertrophy in a similar manner to Ang-II (p < 0.0001), when AD-01 and Ang-II were combined together, this process was abrogated (p < 0.01-0.0001). This mechanism appears to involve a negative feedback loop related to FKBPL (p < 0.05). In human plasma samples, FKBPL concentration was increased in HFpEF compared to controls (p < 0.01); however, similar to NT-proBNP and Gal-3, it was unable to stratify between different forms of HFpEF: acute HFpEF, chronic HFpEF and hypertrophic cardiomyopathy (HCM). FKBPL may be explored for its biomarker and therapeutic target potential in HFpEF. 

Funding

Research and Development Fund, Faculty of Science, University of Technology Sydney

Australian Government Research Training Program (RTP) Stipend

RTP Fee-Offset Scholarship through the University of Technology Sydney

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Chhor M. et al. FK506-binding protein like (FKBPL) has an important role in heart failure with preserved ejection fraction pathogenesis with potential diagnostic utility. Biomolecules. 2023;13(2):395.

Publication Date

18 February 2023

PubMed ID

36830764

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Publisher

MDPI

Version

  • Published Version (Version of Record)