GABA regulation of burst firing in hippocampal astrocyte neural circuit: a biophysical model
journal contributionposted on 03.02.2022, 15:38 by Junxiu Liu, Liam McDaid, Alfonso Araque, John Wade, Jim Harkin, Shvan Karim, David HenshallDavid Henshall, Niamh ConnollyNiamh Connolly, Anju P. Johnson, Andy M. Tyrrell, Jon Timmis, Alan G. Millard, James Hilder, David M. Halliday
It is now widely accepted that glia cells and gamma-aminobutyric acidergic (GABA) interneurons dynamically regulate synaptic transmission and neuronal activity in time and space. This paper presents a biophysical model that captures the interaction between an astrocyte cell, a GABA interneuron and pre/postsynaptic neurons. Specifically, GABA released from a GABA interneuron triggers in astrocytes the release of calcium (Ca2+) from the endoplasmic reticulum via the inositol 1, 4, 5-trisphosphate (IP3) pathway. This results in gliotransmission which elevates the presynaptic transmission probability rate (PR) causing weight potentiation and a gradual increase in postsynaptic neuronal firing, that eventually stabilizes. However, by capturing the complex interactions between IP3, generated from both GABA and the 2-arachidonyl glycerol (2-AG) pathway, and PR, this paper shows that this interaction not only gives rise to an initial weight potentiation phase but also this phase is followed by postsynaptic bursting behavior. Moreover, the model will show that there is a presynaptic frequency range over which burst firing can occur. The proposed model offers a novel cellular level mechanism that may underpin both seizure-like activity and neuronal synchrony across different brain regions.
CommentsThe original article is available at https://www.frontiersin.org/
Published CitationLiu J, et al. GABA regulation of burst firing in hippocampal astrocyte neural circuit: a biophysical model. Front Cell Neurosci. 2019 Jul 23;13:335.
Publication Date23 July 2019
- Physiology and Medical Physics
- FutureNeuro Centre
- Neurological and Psychiatric Disorders
PublisherFrontiers Media SA
- Published Version (Version of Record)