Royal College of Surgeons in Ireland
Genomic-Evidence-of-Sars-Cov-2-Reinfection-in-Ireland.pdf (299.36 kB)

Genomic evidence of SARS-CoV-2 reinfection in Ireland

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journal contribution
posted on 2022-10-24, 13:33 authored by Sinead O'DonnellSinead O'Donnell, J Dean, G Gonzalez, Carr M, J Cafferkey, A Ni Dhuthaigh, Eoghan De BarraEoghan De Barra, C De Gascun, K Burns, K O’Connell, Fidelma FitzpatrickFidelma Fitzpatrick


A 40-year-old healthcare worker (HCW) presented with cough, headache, sore throat, fatigue and myalgia seven months after primary infection with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Symptoms were milder and recovery was faster on the second episode. 


Reinfection with phylogenetically distinct SARS-CoV-2 was confirmed by whole-genome sequencing (WGS). 


Management involved symptomatic treatment and self-isolation. 


The incidence of SARS-CoV-2 reinfection is not well characterised. Infection control precautions may still be required in healthcare facilities, even in previously infected and possibly in vaccinated individuals while SARS-CoV-2 remains in circulation. Further research on the nature and duration of immunity is required to inform public health and infection control policy.



The original article is available at

Published Citation

O’Donnell S. et al. Genomic evidence of SARS-CoV-2 reinfection in Ireland. Ir Med J. 2021;114(5):365

Publication Date

May 2021


  • Beaumont Hospital
  • Clinical Microbiology
  • International Health and Tropical Medicine


Irish Medical Association


  • Published Version (Version of Record)