Royal College of Surgeons in Ireland
Connolly 2019 - Glucose dysregulation in pre-clinical AD.pdf (234.3 kB)

Glucose dysregulation in pre-clinical Alzheimer's disease.

Download (234.3 kB)
journal contribution
posted on 2021-01-19, 12:01 authored by Niamh ConnollyNiamh Connolly, Pierre Theurey, Paola Pizzo
AD is the most common cause of age-related dementia and is consistently accompanied by glucose hypo-metabolism that precedes the onset of clinical symptoms, providing potential for early diagnosis and novel therapeutic interventions. Innovative inter-disciplinary research utilising appropriate pre-clinical models is required to further elucidate the molecular mechanisms, cross-talk with Aβ and tau pathology, and translatable approaches targeted to the early stages of AD. Given that glucose hypo‑metabolism has also been measured in other neurodegenerative diseases, we are excited to watch this field progress.


CeBioND EU Joint Programme for Neurodegenerative Disease Research



The original article is available at

Published Citation

Connolly NMC, Theurey P, Pizzo P. Glucose dysregulation in pre-clinical Alzheimer's disease. Aging (Albany NY). 2019;11(15):5296-5297.

Publication Date

4 August 2019

PubMed ID



  • Centre for Systems Medicine
  • Physiology and Medical Physics

Research Area

  • Neurological and Psychiatric Disorders


Impact Journals, LLC


  • Published Version (Version of Record)