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Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia

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posted on 22.12.2021, 16:18 authored by Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L Atkin, Alexandra E Butler

We have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. Dementia is a recognized complication of type 2 diabetes (T2D) with an increasing prevalence, and AD is the most common cause. However, whilst the stress induced by hypoglycemia was likely the trigger, the contribution of the fall in glucose alone was unclear, given that glucose variability is associated with lower level cognitive function.

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Comments

The original article is available at https://translational-medicine.biomedcentral.com/

Published Citation

Moin ASM, Al-Qaissi A, Sathyapalan T, Atkin SL, Butler AE. Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia. J Transl Med. 2021 ;19(1):131.

Publication Date

31 March 2021

PubMed ID

33789659

Department/Unit

  • RCSI Bahrain

Publisher

BioMed Central

Version

  • Published Version (Version of Record)