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Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

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journal contribution
posted on 20.12.2021, 14:04 by Ebrahim Rajab, Michael B. Keogh, Ashang L Laiva, Fatima Al Hannan, Maryam Fateel, Fatema Abdulwahab, Fatema Al Madhoob, Bassam Alhamer, Samar Y Ghazzal, Abdulla Dawaishan, Sadiq Mahdi, Abdulraham Qareeballa, Sayed M Almosawi, Faisal Falamarzi, Khalifa Elmusharaf, Amer Kamal
The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P < 0.05). Diabetes + GA group had a higher expression density per cell of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) compared to Diabetes + Water (P < 0.05). A similar trend was observed for ATP synthase β-subunit expression (ATPB). Number of PGC-1α positive cells was higher in diabetes compared to control groups (p < 0.05). The GA prevented learning and memory loss in type 2 diabetes. This was associated with greater expression of PGC-1a and a trend for greater ATBP protein expression in the hippocampus.

Funding

Arabian Gulf University

Royal College of Surgeons in Ireland - Medical University Bahrain

History

Comments

The original article can be found at https://www.sciencedirect.com/

Published Citation

Rajab E et al. Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats. Journal of Functional Foods. 2021; 87:104757

Publication Date

16 September 2021

Department/Unit

  • RCSI Bahrain

Publisher

Elsevier

Version

  • Published Version (Version of Record)