Royal College of Surgeons in Ireland
Browse
Hydrogel- and nanocomposite-based drug-delivery strategies in the treatment of vaginal infections.pdf (4.96 MB)

Hydrogel- and nanocomposite-based drug-delivery strategies in the treatment of vaginal infections

Download (4.96 MB)
journal contribution
posted on 2024-05-01, 16:29 authored by Renad AlAnsari, Bushra Hasan, Roshan DeenRoshan Deen, Uwe TorstenUwe Torsten

The reproductive health of women is governed by an optimal balance in the host-microbiota interaction. Depletion of the beneficial vaginal microflora caused by depletion of Lactobacillus species and increased proliferation of pathogens results in gynaecological infections. Among women of reproductive age, vaginal infections are increasingly prevalent. Attaining therapeutic efficacy using conventional formulations remains a challenge as vaginal fluids quickly remove or dilute the therapeutic formulations. Hydrogels have been widely exploited for targeted delivery of therapeutics directly into the vaginal mucus. With a careful choice of polymers (natural, synthetic, or semisynthetic), hydrogels with specific properties, such as stimuli responsiveness, antimicrobial, and muco-adhesiveness, can be tailored for higher therapeutic efficacy. In this review, the advances in hydrogel strategies for the treatment of vaginal infections are presented with emphasis on the types and properties that play a significant role in vaginal drug delivery systems. 

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

AlAnsari R, Hasan B, Deen GR, Torsten U. Hydrogel- and nanocomposite-based drug-delivery strategies in the treatment of vaginal infections. Polymers (Basel). 2024;16(6):775.

Publication Date

12 March 2024

PubMed ID

38543381

Department/Unit

  • RCSI Bahrain

Publisher

MDPI

Version

  • Published Version (Version of Record)