A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.
A2780 ovarian carcinoma cells were kindly donated by Dr. Darren Griffith, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland. Funding derived from the Health Research Board in Ireland under grant number PHD/2007/11 and from Enterprise Ireland under project number CFTD/2009/0127. E. R-H. is supported by the European Union FP7 under a Marie Curie Intra-European Fellowship for Career Development (project NanoSmart). † Dr. A. López-Noriega and Dr. C. L. Hastings contributed equally to this work
CommentsThis article is also available at http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300649/abstract
Published CitationLópez-Noriega A, Hastings CL, Ozbakir B, O'Donnell KE, O'Brien FJ, Storm G, Hennink WE, Duffy GP, Ruiz-Hernández E. Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy. Advanced Healthcare Materials. 2014;3(6):854-9.