Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis.
Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, Staphylococcus aureus and/or Pseudomonas aeruginosa. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.
CommentsThis is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Respiratory Medicine on 9th January 2014 available online: http://www.tandfonline.com/https://doi.org/10.1586/ers.12.59
Published CitationChotirmall SH, Greene CM, McElvaney NG. Expert Review of Respiratory Medicine. 2012;6(6):573-5.
- Beaumont Hospital
- Physiology and Medical Physics