Immune inflammatory and infectious consequences of estrogen in w.pdf (177.69 kB)
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Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis.

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journal contribution
posted on 31.03.2022, 13:51 authored by Sanjay H. Chotirmall, Catherine GreeneCatherine Greene, Noel G McElvaneyNoel G McElvaney

Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, Staphylococcus aureus and/or Pseudomonas aeruginosa. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.

History

Comments

This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Respiratory Medicine on 9th January 2014 available online: http://www.tandfonline.com/https://doi.org/10.1586/ers.12.59

Published Citation

Chotirmall SH, Greene CM, McElvaney NG. Expert Review of Respiratory Medicine. 2012;6(6):573-5.

Publication Date

2012-12-01

PubMed ID

23234443

Department/Unit

  • Beaumont Hospital
  • Physiology and Medical Physics