Royal College of Surgeons in Ireland
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Immunometabolism around the clock

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journal contribution
posted on 2021-08-19, 14:03 authored by Richard Carroll, George Timmons, Mariana P Cervantes-Silva, Oran KennedyOran Kennedy, Annie CurtisAnnie Curtis
Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the feeding/fasting cycle, which shapes whole-body metabolism. However, the exact mechanisms by which the clock controls cellular metabolism have only recently become clear. The molecular clock and related metabolic pathways are also key drivers of immunity. Thus, a natural convergence of circadian biology, metabolism, and immunology has emerged to form a new field that we term ‘circadian immunometabolism’. Expanding our understanding of this field will provide insights into chronic conditions such as obesity, cancer, diabetes, cardiovascular disease, and arthritis.


Impact of circadian control in mitochondrial metabolism in Dendritic Cells and their implications in vaccination. | Funder: The National Council of Science and Technology (CONACYT | Grant ID: The National Council of Science and Technology (CONACYT)

Science Foundation Ireland (Career Development Award (17/CDA/4688))

Irish Research Council Laureate Award (IRCLA/2017/110)

Conacyt Award (440823)



The original article is available at

Published Citation

Carroll RG, Timmons GA, Cervantes-Silva MP, Kennedy OD, Curtis AM. Immunometabolism around the clock. Trends Mol Med. 2019;25(7):612-625.

Publication Date

29 May 2019

PubMed ID



  • Anatomy and Regenerative Medicine
  • School of Pharmacy and Biomolecular Sciences
  • Tissue Engineering Research Group (TERG)

Research Area

  • Health Professions Education
  • Vascular Biology
  • Biomaterials and Regenerative Medicine
  • Immunity, Infection and Inflammation


Elsevier BV


  • Accepted Version (Postprint)