Royal College of Surgeons in Ireland

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Impact of curcumin on p38 MAPK: therapeutic implications

journal contribution
posted on 2023-09-08, 13:50 authored by Hedieh Sadat Shamsnia, Mahtab Roustaei, Danial Ahmadvand, Alexandra ButlerAlexandra Butler, Dorsa Amirlou, Sanam Soltani, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar

Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal transducer and activator of mitogen-activated protein kinase (MAPK) and transcription (JAK/STAT). P38 belongs to the MAPKs, is known as a stress-activated MAPK and is involved in diverse biological responses. P38 is activated in various signaling cascades. P38 plays a role in inflammation, cell differentiation, proliferation, motility and survival. This cascade can serve as a therapeutic target in many disorders. Extensive evidence confirms that curcumin impacts the P38 MAPK signaling pathway, through which it exerts anti-inflammatory, neuroprotective, and apoptotic effects. Hence, curcumin can positively affect inflammatory disorders and cancers, as well as to increase glucose uptake in cells. This review discusses the pharmacological and therapeutic effects of curcumin as effected through p38 MAPK. 



This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:

Published Citation

Shamsnia HS, et al. Impact of curcumin on p38 MAPK: therapeutic implications. Inflammopharmacology. 2023

Publication Date

27 July 2023

PubMed ID



  • RCSI Bahrain


Springer Nature


  • Accepted Version (Postprint)