Impact of exercise on immunometabolism in multiple sclerosis
Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) drives pathology at least in the most common form of MS, relapse-remitting MS (RRMS). The more progressive forms’ mechanisms of action remain more elusive yet an innate immune dysfunction combined with neurodegeneration are likely drivers. Recently, increasing studies have focused on the influence of metabolism in regulating immune cell function. In this regard, exercise has long been known to regulate metabolism, and has emerged as a promising therapy for management of autoimmune disorders. Hence, in this review, we inspect the role of key immunometabolic pathways specifically dysregulated in MS and highlight potential therapeutic benefits of exercise in modulating those pathways to harness an anti-inflammatory state. Finally, we touch upon current challenges and future directions for the field of exercise and immunometabolism in MS.
Funding
Science Foundation Ireland, grant number SFI/FRL/1063400
History
Comments
The original article is available at https://www.mdpi.com/Published Citation
Afzal R, Dowling JK, McCoy CE. Impact of exercise on immunometabolism in multiple sclerosis. J Clin Med. 2020;9(9):3038Publication Date
21 September 2020External DOI
PubMed ID
32967206Department/Unit
- School of Pharmacy and Biomolecular Sciences
Research Area
- Immunity, Infection and Inflammation
- Cancer
- Neurological and Psychiatric Disorders
Publisher
MDPIVersion
- Published Version (Version of Record)