In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
This publication has emanated from research conducted with the financial support of Science Foundation Ireland (05/RFP/CHE0063 and 06/RFP/CHO024/EC07 to M.D. and 06/RFP/CHO006 to C.M.H.)
CommentsThe original article is available at http://aac.asm.org/content/55/5/2487.full.pdf+html
Published CitationDesgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M. In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. Antimicrobial Agents and Chemotherapy 2011;55(5):2487-9
- Clinical Microbiology
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences