In vitro activities of synthetic host defense propeptides process.pdf (416.83 kB)
Download fileIn vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
journal contribution
posted on 2021-04-12, 15:39 authored by Stephane Desgranges, Florie Le Prieult, Alan Daly, Jennifer LydonJennifer Lydon, Marian BrennanMarian Brennan, Dilip K. Rai, Anusha P. Subasinghage, Chandralal M. Hewage, Sally-Ann CryanSally-Ann Cryan, Catherine GreeneCatherine Greene, Noel G McElvaneyNoel G McElvaney, Timothy P. Smyth, Deirdre Fitzgerald HughesDeirdre Fitzgerald Hughes, Hilary HumphreysHilary Humphreys, Marc DevocelleMarc DevocelleThe antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
Funding
This publication has emanated from research conducted with the financial support of Science Foundation Ireland (05/RFP/CHE0063 and 06/RFP/CHO024/EC07 to M.D. and 06/RFP/CHO006 to C.M.H.)
History
Comments
The original article is available at http://aac.asm.org/content/55/5/2487.full.pdf+htmlPublished Citation
Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M. In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. Antimicrobial Agents and Chemotherapy 2011;55(5):2487-9Publication Date
2011-05-01External DOI
PubMed ID
21343449Department/Unit
- Chemistry
- Clinical Microbiology
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences
- Medicine
- Undergraduate Research
CC BY-NC-SA 4.0