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Incidence and persistence of psychotic experiences in the general population.....pdf (10.39 MB)

Incidence and persistence of psychotic experiences in the general population: systematic review and meta-analysis

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Background and hypothesis: Psychotic experiences (PEs) are associated with increased risk for mental disorders, in particular persistent PEs. PEs therefore might be useful within intervention research. We sought to systematically determine the incidence and persistence of PEs in the general population.

Study design: A double-blind search of databases (Embase, Pubmed PMC, Psychinfo, Medline, and Web of Science) from inception to January 2023 and data extraction, were conducted. Study quality was assessed using the NIH assessment tool. Random effects models were conducted to calculate pooled incidence rate per person-year and proportion of persistent PEs per year. Age and study design were all examined using subgroup analyses. Demographic, risk factors, and outcomes for incidence and persistence of PEs were reported in a narrative synthesis.

Study results: Using a double-blind screening method for abstract (k = 5763) and full text (k = 250) were screened. In total 91 samples from 71 studies were included, of which 39 were included in a meta-analysis (incidence: k = 17, n = 56 089; persistence: k = 22, n = 81 847). Incidence rate was 0.023 per person-year (95% CI [0.0129;0.0322]). That is, for every 100 people, 2 reported first onset PEs in a year. This was highest in adolescence at 5 per 100(13-17 years). The pooled persistence rate for PEs was 31.0% (95% CI [26.65,35.35]) This was highest in adolescence at 35.8%. Cannabis was particularly associated with incidence of PEs, and persistence of PEs were associated with multiple mental disorders.

Conclusions: Each year incidence of PEs is 2 of every 100 people, and persists each year in 31% of cases, this risk is highest in adolescents

Funding

iHEAR study, a European Research Council funded project (grant number: 724809)

Wellcome Trust Innovations Award, number 220438Z/20/Z)

Science Foundation Ireland (SFI) under Grant Number 16/ RC/3948415

European Regional Development Fund

FutureNeuro industry partners

Health Research Board Investigator Lead Project (ILP-PHR-2019-009)

History

Comments

The original article is available at https://academic.oup.com/

Published Citation

Staines L. et al. Incidence and persistence of psychotic experiences in the general population: systematic review and meta-analysis. Schizophr Bull. 2023;49(4):1007-1021

Publication Date

17 April 2023

PubMed ID

37402250

Department/Unit

  • Beaumont Hospital
  • Psychiatry

Publisher

Oxford University Press

Version

  • Published Version (Version of Record)

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