Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
Version 2 2021-09-02, 16:14
Version 1 2019-11-22, 15:12
journal contribution
posted on 2021-09-02, 16:14 authored by Amos Matsiko, Tanya J. Levingstone, John GleesonJohn Gleeson, Fergal O'BrienFergal O'BrienIncorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.
Funding
Enterprise Ireland, Commercialization Fund Technology
History
Comments
The original article is available at onlinelibrary.wiley.comPublished Citation
Matsiko A, Levingstone TJ, Gleeson JP, O'Brien FJ. Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Advanced Healthcare Materials. 2015;4(8):1175-9.Publication Date
2015-06-03External DOI
PubMed ID
25800862Department/Unit
- Anatomy and Regenerative Medicine
- Tissue Engineering Research Group (TERG)
- Amber (Advanced Material & Bioengineering Research) Centre
