Royal College of Surgeons in Ireland
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Inflammatory bowel disease and associated cardiovascular disease outcomes: a systematic review

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journal contribution
posted on 2023-03-21, 17:53 authored by Vikash Jaiswal, Nitya Batra, Mehak Dagar, Swatika Butey, Helen Huang, Jia Ee Chia, Sidra Naz, Evbayekha O Endurance, Nishchita Raj, Srushti Patel, Dipansha Maroo, Song Peng Ang, Muhammed Hanif, Dattatreya Mukherjee, Zouina Sarfraz, Abhigan Babu Shrestha, David Song

Background: There is limited and conflicting data available regarding the cardiovascular disease outcomes associated with inflammatory bowel disease (IBD).

Objective: We aim to perform a systematic review to evaluate the cardiovascular outcomes and mortality associated with IBD patients.

Methods: A systematic literature search has been performed on PubMed, Embase, Cochrane, and Scopus from inception till May 2022 without any language restrictions.

Results: A total of 2,029,941 patients were included in the analysis from 16 studies. The mean age of the patients was 45.6 years. More females were found compared with males (57% vs 43%). The most common risk factors for cardiovascular disease (CVD) included smoking (24.19%) and alcohol (4.60%). The most common comorbidities includes hypertension (30%), diabetes mellitus (14.41%), dyslipidemia (18.42%), previous CVD (22%), and renal disease (10%). Among outcomes, all-cause mortality among IBD patients was 1.66%; ulcerative colitis (UC): 15.92%; and Crohn disease (CD): 0.30%. Myocardial Infarction (MI) among IBD patients were 1.47%, UC: 30.96%; and CD: 34.14%. CVD events among IBD patients were 1.95%. Heart failure events among IBD patients were 5.49%, stroke events among IBD patients were 0.95%, UC: 2.63%, and CD: 2.41%, respectively.

Conclusion: IBD patients are at higher risk for adverse cardiovascular outcomes, especially in women. Although there remains a lack of concrete treatment algorithms and assessment parameters that better characterize IBD risk factors, nutritional modifications and physical activity should be at the forefront of CVD prevention in IBD.



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Published Citation

Jaiswal V. et al. Inflammatory bowel disease and associated cardiovascular disease outcomes: a systematic review. Medicine (Baltimore). 2023;102(6):e32775

Publication Date

10 February 2023

PubMed ID



  • Undergraduate Research


Lippincott Williams & Wilkins


  • Published Version (Version of Record)