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Integrating point-of-care bacterial fluorescence imaging-guided care with continued wound measurement for enhanced wound area reduction monitoring

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posted on 2024-03-07, 13:57 authored by Rosemarie Derwin, Declan PattonDeclan Patton, Helen StrappHelen Strapp, Zena MooreZena Moore

Aim: This prospective observational study investigated wound area reduction (WAR) outcomes in a complex wound population composed of non-healing acute and chronic wounds. The relationship between bacterial autofluorescence signals and WAR was investigated. Area measurements were collected both manually and digitally, and both methods were compared for accuracy.

Methods: Twenty-six participants with 27 wounds of varying etiologies were observed twice weekly for two weeks. Digital wound measurement, wound bacterial status assessment, and targeted debridement were performed through a point-of-care fluorescence imaging device (MolecuLight® i: X, MolecuLight Inc, Toronto, Canada). The wound area reduction (WAR) rate was calculated using baseline and last visit measurements. Statistical analyses, including t-tests, Fisher exact tests, the Wilcoxon signed rank test for method comparison, and ANOVA for bacterial subgroups, were applied as pertinent.

Results: The overall average WAR was -3.80 cm2, or a decrease of 46.88% (manual measurement), and -2.62 cm2, or a 46.05% decrease (digital measurement via MolecuLight® device). There were no statistically significant differences between the WAR of acute and chronic wounds (p = 0.7877). A stepwise correlation between the WAR and bacterial status classification per fluorescence findings was observed, where persistent bacteria resulted in worse WAR outcomes. An overestimation of wound area by manual measurement was 23% on average.

Conclusion: Fluorescence imaging signals were linked to WAR outcome and could be considered predictive. Wounds exhibiting bacterial loads that persisted at the end of the study period had worse WAR outcomes, while those for which management was able to effectively remove them demonstrated greater WAR. Manual measurement of the wound area consistently overestimated wound size when compared to digital measurement. However, if performed by the same operator, the overestimation was uniform enough that the WAR was calculated to be close to accurate. Notwithstanding, single wound measurements are likely to result in overestimation.

Funding

Irish Research Council, Enterprise Partnership Scheme. Project ID: EPSPG/2016/159

Open access funding provided by IReL

History

Data Availability Statement

The data presented in this study are available on request from the corresponding author. The data are not publicly available due to privacy

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Derwin R, Patton D, Strapp H, Moore Z. Integrating point-of-care bacterial fluorescence imaging-guided care with continued wound measurement for enhanced wound area reduction monitoring. Diagnostics (Basel). 2023;14(1):2.

Publication Date

19 December 2023

PubMed ID

38201311

Department/Unit

  • School of Nursing and Midwifery

Publisher

MDPI

Version

  • Published Version (Version of Record)

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