Royal College of Surgeons in Ireland
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Integrins as therapeutic targets for SARS-CoV-2

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journal contribution
posted on 2022-06-01, 15:21 authored by Timothy E Gressett, Danielle NaderDanielle Nader, Juan Pablo Robles, Tione Buranda, Steven KerriganSteven Kerrigan, Gregory Bix

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus of the genus Betacoronavirus. Its genome is composed of four structural proteins known as spike (S), envelope (E), membrane (M), and nucleocapsid (N), of which E, M, and N are integrated into the viral envelope. The S glycoprotein, which protrudes from the surface of mature virions as a spike, is essential for virus attachment, fusion, and entry into the host cell.



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Published Citation

Gressett TE, Nader D, Robles JP, Buranda T, Kerrigan SW, Bix G. Integrins as therapeutic targets for SARS-CoV-2. Front Cell Infect Microbiol. 2022;12:892323.

Publication Date

29 April 2022

PubMed ID



  • School of Pharmacy and Biomolecular Sciences


Frontiers Media S.A.


  • Published Version (Version of Record)