Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients.pdf (917.67 kB)
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Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?

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posted on 10.02.2022, 16:51 authored by Nitya Kumar, AbdulKarim AbdulRahman, Abdulla Ismaeel AlAwadhi, Manaf AlQahtani
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is known to suppress the antioxidant system and is likely to aggravate severity of COVID-19, which results in a pro-oxidant response. This possible association has not been explored adequately in human studies. In this research, we report that the occurrence of non-invasive ventilation, intubation or death-all of which are indicative of severe COVID-19, are not significantly different in hospitalized COVID-19 patients with and without G6PDd (4.6 vs. 6.4%, p = 0.33). The likelihood of developing any of these severe outcomes were slightly lower in patients with G6PDd after accounting for age, nationality, presence of comorbidities and drug interventions (Odds ratio 0.40, 95% confidence intervals 0.142, 1.148). Further investigation that extends to both, hospitalized and non-hospitalized COVID-19 patients, is warranted to study this potential association.

Funding

RCSI Bahrain

History

Comments

The original article is available at https://www.nature.com/articles

Published Citation

Kumar N, AbdulRahman A, AlAwadhi AI, AlQahtani M. Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients? Sci Rep. 2021;11(1):19213

Publication Date

28 September 2021

PubMed ID

34584152

Department/Unit

  • RCSI Bahrain

Publisher

Springer Nature Limited

Version

  • Published Version (Version of Record)