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Lipid nanoparticles as promising carriers for mRNA vaccines for viral lung infections.pdf (10.11 MB)

Lipid nanoparticles as promising carriers for mRNA vaccines for viral lung infections

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journal contribution
posted on 2023-05-17, 16:39 authored by Mena Hajiaghapour Asr, Fatemeh Dayani, Fatemeh Saedi Segherloo, Ali Kamedi, Andrew O' Neill, Ronan MacLoughlinRonan MacLoughlin, Mohammad Doroudian

In recent years, there has been an increase in deaths due to infectious diseases, most notably in the context of viral respiratory pathogens. Consequently, the focus has shifted in the search for new therapies, with attention being drawn to the use of nanoparticles in mRNA vaccines for targeted delivery to improve the efficacy of these vaccines. Notably, mRNA vaccine technologies denote as a new era in vaccination due to their rapid, potentially inexpensive, and scalable development. Although they do not pose a risk of integration into the genome and are not produced from infectious elements, they do pose challenges, including exposing naked mRNAs to extracellular endonucleases. Therefore, with the development of nanotechnology, we can further improve their efficacy. Nanoparticles, with their nanometer dimensions, move more freely in the body and, due to their small size, have unique physical and chemical properties. The best candidates for vaccine mRNA transfer are lipid nanoparticles (LNPs), which are stable and biocompatible and contain four components: cationic lipids, ionizable lipids, polyethylene glycols (PEGs), and cholesterol, which are used to facilitate cytoplasmic mRNA delivery. In this article, the components and delivery system of mRNA-LNP vaccines against viral lung infections such as influenza, coronavirus, and respiratory syncytial virus are reviewed. Moreover, we provide a succinct overview of current challenges and potential future directions in the field. 

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The original article is available at https://www.mdpi.com/

Published Citation

Hajiaghapour Asr M. et al. Lipid nanoparticles as promising carriers for mRNA vaccines for viral lung infections. Pharmaceutics. 2023;15(4):1127.

Publication Date

3 April 2023

PubMed ID

37111613

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Publisher

MDPI

Version

  • Published Version (Version of Record)