Making Medicines Baby Size.......................pdf (1.72 MB)
Download file

Making medicines baby size: the challenges in bridging the formulation gap in neonatal medicine

Download (1.72 MB)
journal contribution
posted on 06.07.2021, 15:46 by Fiona O'BrienFiona O'Brien, David Clapham, Kamelia KrysiakKamelia Krysiak, Hannah Batchelor, Peter Field, Grazia Caivano, Marisa Pertile, Anthony Nunn, Catherine Tuleu
The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products.

Funding

Medication safety in neonates | Funder: School of Pharmacy, Royal College of Surgeons in Ireland | Grant ID: Clement Archer Scholarship

History

Comments

The original article is available at https://www.mdpi.com

Published Citation

O'Brien F, Clapham D, Krysiak K, Batchelor H, Field P, Caivano G, Pertile M, Nunn A, Tuleu C. Making medicines baby size: the challenges in bridging the formulation gap in neonatal medicine. Int J Mol Sci. 2019;20(11):2688.

Publication Date

31 May 2019

PubMed ID

31159216

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Biomaterials and Regenerative Medicine

Publisher

MDPI AG

Version

  • Published Version (Version of Record)