Maternal outcomes and risk factors for COVID-19 severity among pregnant women.pdf (880.05 kB)
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
journal contributionposted on 2023-09-18, 11:15 authored by Manon Vouga, Brian ClearyBrian Cleary, Fergal MaloneFergal Malone, Alice Panchaud
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.
CommentsThe original article is available at https://www.nature.com/
Published CitationVouga M, et al. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep. 2021 Jul;11(1):13898.
Publication Date6 July 2021
- Obstetrics and Gynaecology
- School of Pharmacy and Biomolecular Sciences
- Gynaecology, Obstetrics and Perinatal Health
PublisherSpringer Science and Business Media LLC
- Published Version (Version of Record)
HumansPregnancy Complications, InfectiousPremature BirthPregnancy OutcomeRisk FactorsCase-Control StudiesPregnancyAdultPregnant WomenFemaleCOVID-19SARS-CoV-2Emerging Infectious DiseasesPreterm, Low Birth Weight and Health of the NewbornVaccine RelatedPreventionClinical ResearchPneumoniaConditions Affecting the Embryonic and Fetal PeriodsPneumonia & InfluenzaBiodefenseLungInfectious DiseasesPerinatal Period - Conditions Originating in Perinatal PeriodPediatricInfant MortalityReproductive health and childbirthpandemicscoronavirus