Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization.

Poovelikunnel, Toney; Budri, Paulo E.; Shore, Anna C.; Coleman, David C.; Humphreys, Hilary; Fitzgerald Hughes, Deirdre

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Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization.

Version 3 2022-03-01, 12:35

Version 2 2022-03-01, 12:32

Version 1 2019-11-22, 15:20

journal contribution

posted on 2022-03-01, 12:35 authored by Toney PoovelikunnelToney Poovelikunnel, Paulo E. Budri, Anna C. Shore, David C. Coleman, Hilary HumphreysHilary Humphreys, Deirdre Fitzgerald HughesDeirdre Fitzgerald Hughes

Sequential methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients following attempted mupirocin nasal decolonization showed an increase in mupirocin resistance (MR) from 6.6% to 20%. MR isolates from patients who failed decolonization yielded indistinguishable spa types and carried multiple antimicrobial and antiseptic resistance genes, which may guide infection control and prevention.

Funding

Health Research Board Ireland (HPF/2013-495). Pfizer and Astellas.

History

Comments

The original article is available at https://aac.asm.org

Published Citation

Poovelikunnel TT, Budri PE, Shore AC, Coleman DC, Humphreys H, Fitzgerald-Hughes D. Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization. Antimicrobial Agents and Chemotherapy. 2018;62(9):pii: e00819-18.