Royal College of Surgeons in Ireland
EXCLI-21-317.pdf (991.42 kB)

Molecular mechanisms linking stress and insulin resistance

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journal contribution
posted on 2022-10-24, 14:57 authored by Habib Yaribeygi, Mina Maleki, Alexandra ButlerAlexandra Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.



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Published Citation

Yaribeygi H, Maleki M, Butler AE, Jamialahmadi T, Sahebkar A. Molecular mechanisms linking stress and insulin resistance. EXCLI J. 2022;21:317-334.

Publication Date

24 January 2022

PubMed ID



  • RCSI Bahrain




  • Published Version (Version of Record)