More on ‘Association between ABO blood groups and risk of SARS-CoV-2 pneumonia’
journal contributionposted on 2022-07-26, 16:25 authored by Jamie O'SullivanJamie O'Sullivan, Soracha Enright Ward, Helen FogartyHelen Fogarty, James O'DonnellJames O'Donnell
We read with interest the recent report from Li et al.1 describing an association between ABO blood groups and risk of SARS‐CoV‐2 pneumonia. In an initial study of 265 patients with COVID, the authors observed that blood group O individuals were significantly underrepresented amongst patients who required hospitalization for severe COVID‐19 infection (P < 0·01). Conversely, blood group A was significantly more common in patients with severe COVID‐19 compared to the local population (P = 0·017). Subsequently, in a larger validation cohort that included 2 153 patients with COVID‐19, this ABO effect was reproduced with blood group O again being associated with a significant protective effect (P < 0·001). In keeping with these data, another independent study (n = 2 173) also reported that blood group O was associated with reduced susceptibility to severe COVID‐19.2 Since the pathogenesis underlying COVID‐19 remains poorly understood, we believe that these novel findings provide interesting insights into biological mechanisms that may contribute to interindividual differences in COVID‐19 susceptibility.
CommentsThis is the pre-peer reviewed version of the following article: O'Sullivan JM, Ward S, Fogarty H, O'Donnell JS. More on 'association between ABO blood groups and risk of SARS-CoV-2 pneumonia'. Br J Haematol. 2020;190(1):27-28.], which has been published in final form at https://doi.org/10.1111/bjh.16845. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Published CitationO'Sullivan JM, Ward S, Fogarty H, O'Donnell JS. More on 'Association between ABO blood groups and risk of SARS-CoV-2 pneumonia'. British Journal of Haematology. 2020;190(1):27-28.
Publication Date18 May 2020
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
- Vascular Biology
- Health Professions Education
- Immunity, Infection and Inflammation
- Accepted Version (Postprint)
SARS VirusPneumonia, ViralCoronavirus InfectionsBlood Group AntigensPandemicsBetacoronavirusCOVID-19SARS-CoV-2ImmunologyCardiorespiratory Medicine and HaematologyCoronaviruspneumoniaABOblood group Ovon Willebrand factorvon Willebrand diseasebleeding disordersClinical Pharmacology and TherapeuticsHaematologyInfectious DiseasesRespiratory Diseases