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Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: the Hamburg City Health Study COVID programme

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posted on 11.03.2022, 17:10 authored by Elina Larissa Petersen, Alina Goßling, Gerhard Adam, Martin Aepfelbacher, Christian-Alexander Behrendt, Ersin Cavus, Bastian Cheng, Nicole Fischer, Jürgen Gallinat, Simone Kühn, Christian Gerloff, Uwe Koch-Gromus, Martin Härter, Uta Hanning, Tobias B Huber, Stefan Kluge, Johannes K Knobloch, Piotr Kuta, Christian Schmidt-Lauber, Marc Lütgehetmann, Christina Magnussen, Carola Mayer, Kai Muellerleile, Julia Münch, Felix Leonard Nägele, Marvin Petersen, Thomas Renné, Katharina Alina Riedl, David Leander Rimmele, Ines Schäfer, Holger Schulz, Enver Tahir, Benjamin Waschki, Jan-Per Wenzel, Tanja Zeller, Andreas Ziegler, Götz Thomalla, Raphael Twerenbold, Stefan Blankenberg
Aims: Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals after mild to moderate SARS-CoV-2 infection compared with controls from the general population.
Methods and results: Four hundred and forty-three mainly non-hospitalized individuals were examined in median 9.6 months after the first positive SARS-CoV-2 test and matched for age, sex, and education with 1328 controls from a population-based German cohort. We assessed pulmonary, cardiac, vascular, renal, and neurological status, as well as patient-related outcomes. Bodyplethysmography documented mildly lower total lung volume (regression coefficient -3.24, adjusted P = 0.014) and higher specific airway resistance (regression coefficient 8.11, adjusted P = 0.001) after SARS-CoV-2 infection. Cardiac assessment revealed slightly lower measures of left (regression coefficient for left ventricular ejection fraction on transthoracic echocardiography -0.93, adjusted P = 0.015) and right ventricular function and higher concentrations of cardiac biomarkers (factor 1.14 for high-sensitivity troponin, 1.41 for N-terminal pro-B-type natriuretic peptide, adjusted P ≤ 0.01) in post-SARS-CoV-2 patients compared with matched controls, but no significant differences in cardiac magnetic resonance imaging findings. Sonographically non-compressible femoral veins, suggesting deep vein thrombosis, were substantially more frequent after SARS-CoV-2 infection (odds ratio 2.68, adjusted P < 0.001). Glomerular filtration rate (regression coefficient -2.35, adjusted P = 0.019) was lower in post-SARS-CoV-2 cases. Relative brain volume, prevalence of cerebral microbleeds, and infarct residuals were similar, while the mean cortical thickness was higher in post-SARS-CoV-2 cases. Cognitive function was not impaired. Similarly, patient-related outcomes did not differ.
Conclusion: Subjects who apparently recovered from mild to moderate SARS-CoV-2 infection show signs of subclinical multi-organ affection related to pulmonary, cardiac, thrombotic, and renal function without signs of structural brain damage, neurocognitive, or quality-of-life impairment. Respective screening may guide further patient management.

Funding

Senat und Behörde für Wissenschaft, Forschung, Gleichstellung und Bezirke (BWFGB) (Reference E43026-03.HCHS)

Hamburg and the Deutsche Forschungsgemeinschaft (Grant Number TH1106/5-1; AA93/2-1)

History

Comments

The original article is available at https://academic.oup.com/

Published Citation

Petersen EL, et al. Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: the Hamburg City Health Study COVID programme. Eur Heart J. 2022:ehab914.

Publication Date

6 January 2022

PubMed ID

34999762

Department/Unit

  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Publisher

Oxford University Press

Version

  • Published Version (Version of Record)