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Neutrophils: need for standardized nomenclature

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journal contribution
posted on 22.12.2021, 16:25 by Ellen McKenna, Aisling Ui Mhaonaigh, Richard Wubben, Amrita Dwivedi, Tim Hurley, Lynne A Kelly, Nigel J Stevenson, Mark A Little, Eleanor J Molloy
Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, polymorphonuclear neutrophils (PMN), granulocytic myeloid derived suppressor cells (G-MDSC), low density neutrophils (LDN) and tumor associated neutrophils (TANS). This lack of standardized nomenclature for neutrophils suggest that biologically distinct populations of neutrophils exist, particularly in disease, when in fact these may simply be a manifestation of the plasticity of the neutrophil as opposed to unique populations. In this review, we profile the surface markers and granule expression of each stage of granulopoiesis to offer insight into how each stage of maturity may be identified. We also highlight the remarkable surface marker expression profiles between the supposed neutrophil populations.

History

Comments

The original article is available at https://www.frontiersin.org/

Published Citation

McKenna E. et al. Neutrophils: need for standardized nomenclature. Front Immunol. 2021;12:602963.

Publication Date

15 April 2021

PubMed ID

33936029

Department/Unit

  • RCSI Bahrain

Publisher

Frontiers Research Foundation

Version

  • Published Version (Version of Record)