Novel Improved Synthesis of HSP70 Inhibitor Pifithrin-?. In Vitr.pdf (1.39 MB)

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.

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posted on 23.11.2019, 11:50 by Aoife M. McKeon, Alan Egan, Jay Chandanshive, Helena McMahon, Darren M. Griffith

We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comprising HSP70 inhibitor pifithrin-μ and cisplatin or oxaliplatin is reported. We have determined, using the Chou-Talalay method, (i) moderate synergistic and synergistic effects in co-treating PC-3 prostate cancer cells with pifithrin-μ and cisplatin and (ii) significant synergistic effects including strong synergism in cotreating HT29 colorectal cancer cells with oxaliplatin and pifithrin-μ.

Funding

Science Foundation Ireland. Institute of Technology, Tralee.

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The original article is available at http://www.mdpi.com

Published Citation

McKeon AM, Egan A, Chandanshive J, McMahon H, Griffith DM. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules. 2016;21(7). pii: E949

Publication Date

21/07/2016

Publisher

MDPI AG

PubMed ID

27455212

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Royal College of Surgeons in Ireland

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