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Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori.

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posted on 13.01.2022, 12:18 authored by Donal M. Keogan, Brendan Twamley, Deirdre Fitzgerald HughesDeirdre Fitzgerald Hughes, Darren M. Griffith

Reaction of Bi(NO3)3 with benzohydroxamic acid (Bha) and salicylhydroxamic acid (Sha) gives the novel Bi(iii) complexes [Bi2(Bha-1H)2(μ-Bha-1H)2(η(2)-NO3)2] () and [Bi6(CH3OH)2(η(1)-NO3)2(η(2)-NO3)(OH2)2(Sha-1H)12](NO3)2 (). X-ray crystal structure of reveals two hydroxamato coordination modes; bidentate bridging (O, O') and bidentate non-bridging (O, O') and of reveals one coordination mode; bidentate bridging (O, O'). , specifically designed to and demonstrated to inhibit the activity of urease, exhibits excellent antibacterial activity against three strains of Helicobacter pylori with MIC ≥ 16 μg mL(-1).

Funding

Irish Research Council. Royal College of Surgeons in Ireland

History

Comments

The original article is available at http://www.rsc.org

Published Citation

Keogan DM, Twamley B, Fitzgerald-Hughes D, Griffith DM. Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori. Dalton Transactions. 2016;45(27):11008-14.

Publication Date

2016-07-05

PubMed ID

27314129

Department/Unit

  • Beaumont Hospital
  • Clinical Microbiology