Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population _ Elsevier Enhanced Reader.pdf (15.91 MB)Download file
Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population
journal contributionposted on 2023-03-02, 13:22 authored by Smita Salunke, Fiona O'BrienFiona O'Brien, David Cheng Thiam Tan, David Harris, Marie-Christine Math, Tina Ariën, Sandra Klein, Carsten Timpe, European Paediatric Formulation Initiative EuPFI
Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies are available to select a suitable approach and guide formulation scientists for development of adult formulations. However, there is paucity of available literature for selection of technology and overcoming the challenges in paediatric formulation development. The need for flexible dosing, and the limited knowledge of the safety of many formulation excipients in paediatric subjects, impose significant constraints and in some instances require adaptation of the approaches taken to formulating these drugs for the adult population. Selection of the best drug delivery system for paediatrics requires an efficient, systematic approach that considers a drug's physical and chemical properties and the targeted patient population's requirements. This review is a step towards development of a strategy for the design of solubility enhancing paediatric formulations of highly insoluble drugs. The aim of this review is to provide an overview of different approaches and strategies to consider in order to assist development of paediatric formulation for poorly water-soluble drugs with the provision of examples of some marketed products. In addition, it provides recommendations to overcome the range of challenges posed by these strategies and adaptations of the adult approach/product presentation required to enable paediatric drug development and administration.
CommentsThe original article is available at https://www.sciencedirect.com/
Published CitationSalunke S. et al. Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population. Adv Drug Deliv Rev. 2022;190:114507.
Publication Date29 August 2022
- School of Pharmacy and Biomolecular Sciences
- Biomaterials and Regenerative Medicine
PublisherElsevier Science Publishers
- Published Version (Version of Record)
WaterPharmaceutical PreparationsExcipientsDrug Delivery SystemsAdministration, OralSolubilityAdultChildCyclodextrinFormulationLipid based drug deliveryNanocrystalPaediatric formulationPoorly water soluble drugsSolid dispersionSolubility enhancing technologiesPharmacology & Pharmacysolubility-enabling technologyChildren