Royal College of Surgeons in Ireland
Outcomes-after-Laser-Ablation-in-Twin-to-twin-Transfusion-Syndrome.pdf (181.27 kB)

Outcomes after laser ablation in twin-to-twin transfusion syndrome

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journal contribution
posted on 2023-09-15, 16:09 authored by Amina Javaid, A Alsudani, W Tadasse, SW Lindow, Fergal MaloneFergal Malone

Aim: Twin-to-Twin Transfusion Syndrome (TTTS) is associated with high perinatal morbidity and mortality in monochorionic twins. Ultrasound Doppler studies of the umbilical arteries (UAD) have a vital role in fetal assessment in multiple pregnancies complicated by TTTS. The Quintero staging is used to grade the severity of the condition. 

Methods: The aim of the study was to describe UAD findings and outcomes in a cohort of 78 twin pregnancies treated with laser ablation. 

Results: Of the 78 twin pregnancies, 39 women had two surviving babies (50%) and 17 (22%) had a single survivor. The most frequent Quintero stage at diagnosis was Stage three (38%, 30/78), followed by Stage two (32%, 25/78), Stage one (24%, 19/78) and Stage four (5%, 4/78). The Quintero stage was not significantly associated with survival (chi sq 5.31 p=0.151). While 50% of pregnancies had normal UAD at the time of TTTS diagnosis, 50% had at least one abnormal UAD. A normal UAD was not associated with higher survival (68% v 53%, chi sq 3.26 p=0.071). 

Conclusion: Laser ablation for TTTS was associated with 50% double survival and 22% single survival. UAD abnormalities or the Quintero stage was not associated with survival after laser ablation.



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Published Citation

Javaid A, Alsudani A, Tadasse W, Lindow S.W, Malone F. Outcomes after laser ablation in twin-to-twin transfusion syndrome. IMJ. 2021;114;3:290

Publication Date

March 2021


  • Obstetrics and Gynaecology

Research Area

  • Gynaecology, Obstetrics and Perinatal Health


Irish Medical Association


  • Published Version (Version of Record)

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