Patient and public involvement (PPI) in preclinical research: a scoping review protocol[version 2; peer review: 2 approved]
Introduction: Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possible degree. The evidence base for the positive impact of PPI on clinical research continues to grow, but the role of PPI in preclinical research (an umbrella term encompassing 'basic', 'fundamental', 'translational' or 'lab-based' research) remains limited. As funding bodies and policymakers continue to increase emphasis on the relevance of PPI to preclinical research, it is timely to map the PPI literature to support preclinical researchers involving the public, patients, or other service users in their research. Therefore, the aim of this scoping review is to explore the literature on patient and public involvement in preclinical research from any discipline.
Methods: This scoping review will search the literature in Medline (PubMed), Embase, CINAHL, PsycINFO, Web of Science Core Collection, Scopus, and OpenGrey.net to explore the application of PPI in preclinical research. This review will follow the Joanna Briggs Institute (JBI) guidelines for scoping reviews. It will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Two reviewers will independently review articles for inclusion in the final review. Data extraction will be guided by the research questions. The PPI advisory panel will then collaboratively identify themes in the extracted data.
Discussion: This scoping review will provide a map of current evidence surrounding preclinical PPI, and identify the body of literature on this topic, which has not been comprehensively reviewed to date. Findings will inform ongoing work of the research team, support the work of other preclinical researchers aiming to include PPI in their own research, and identify knowledge and practice gaps. Areas for future research will be identified.
Irish Rugby Football Union Charitable Trust (IRFUCT)
Advanced Materials and Bioengineering Research Centre (AMBER) through Science Foundation Ireland (SFI/12/RC/2278 and SFI/12/RC/2278_P2)
Clement Archer PhD Scholarship from the School of Pharmacy and Biomolecular Sciences at RCSI
CommentsThe original article and an updated version may be available on https://hrbopenresearch.org/
Published CitationCarroll P. et al. Patient and public involvement (PPI) in preclinical research: a scoping review protocol [version 2; peer review: 2 approved]. HRB Open Res. 2021;4:61.
Publication Date31 August 2021
- School of Pharmacy and Biomolecular Sciences
- Tissue Engineering Research Group (TERG)
- Anatomy and Regenerative Medicine
- Amber (Advanced Material & Bioengineering Research) Centre
- Population Health and Health Services
- Health Professions Education
PublisherF1000 Research Ltd