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Download filePersonalized approaches to the treatment of hemostatic disorders
journal contribution
posted on 2021-07-02, 14:14 authored by Roger PrestonRoger Preston, Jamie O'SullivanJamie O'SullivanThe last 20 years has seen dramatic improvements in the
clinical management of hemostatic and thrombotic disorders.
We have witnessed the introduction of novel therapeutic
agents into the clinic, including direct oral anticoagulants
(DOACs), and the rapid evolution of personalized therapy for
patients with the development of high-throughput genetic
analysis and gene therapy. Moreover, growing awareness of
nonlinear genotype-phenotype correlations in disease presentation, including bleeding or thrombosis risk, has catalyzed the
concept of tailored individualized therapies. Many of these
clinical milestones have been made possible by improved
understanding of the fundamental biology and thus pathophysiology underpinning hemostatic disorders, as well as
development of novel technologies and diagnostic tools. This
review series aims to provide an overview of some of these
advancements, with a particular focus on novel and personalized approaches to the management of disorders of hemostasis
and thrombosis.
History
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The original article is available at https://www.thieme-connect.de/Published Citation
Preston RJS, O'Sullivan JM. Personalized approaches to the treatment of hemostatic disorders. Semin Thromb Hemost. 2021 47(2):117-119.Publication Date
26 Feb 2021External DOI
PubMed ID
33636743Department/Unit
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
Research Area
- Cancer
- Vascular Biology
- Immunity, Infection and Inflammation
- Health Professions Education
Publisher
Georg Thieme Verlag KGVersion
- Accepted Version (Postprint)