Plasma lipid alterations in young adults with psychotic experiences: a study from the Avon Longitudinal Study of Parents and Children cohort
Background: Psychotic experiences (PEs) are associated with an increased risk of future psychotic and non-psychotic mental disorders. The identification of biomarkers of PEs may provide insights regarding the underlying pathophysiology.
Methods: The current study applied targeted lipidomic approaches to compare plasma lipid profiles in participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who did (n = 206) or did not (n = 206) have PEs when aged approximately 24 years.
Results: In total, 202 lipids including 8 lipid classes were measured by using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Eight lipid clusters were generated. Thirteen individual lipids were nominally significantly higher in the PEs group compared to the control group. After correction for multiple comparisons, 9 lipids comprising 3 lysophosphatidylcholines (LPCs), 2 phosphatidylcholines (PCs) and 4 triacylglycerols (TGs) remained significant. In addition, PEs cases had increased levels of TGs and LPCs with a low double bond count.
Conclusions: These findings indicate plasma lipidomic abnormalities in individuals experiencing PEs. The lipidomic profile measures could aid our understanding of the underlying pathophysiological mechanisms.
Irish Health Research Board (grant HRA-PHR-2015-1293)
Science Foundation Ireland under Grant Number 16/RC/3948
European Research Council (647783)
Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z), the Health Service Executive National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland.
European Research Council Consolidator Award (iHEAR 724809)
NIHR Biomedical Research Centre at University Hospitals Bristol
Weston NHS Foundation Trust and the University of Bristol
The UK Medical Research Council and Wellcome (Grant Ref: 217065/Z/19/Z)
Medical Research Council (MR/M006727/1)
CommentsThe original article is available at https://www.sciencedirect.com/
Published CitationYin X. et al. Plasma lipid alterations in young adults with psychotic experiences: a study from the Avon Longitudinal Study of Parents and Children cohort. Schizophr Res. 2022;243:78-85
Publication Date1 March 2022
- Beaumont Hospital
- Neurological and Psychiatric Disorders
- Immunity, Infection and Inflammation
- Published Version (Version of Record)