Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy
Transient prothrombotic disorders caused by plateletactivating antibodies against platelet factor 4 (PF4) include heparin-induced thrombocytopenia (HIT), spontaneous HIT syndrome,1 and, most recently, vaccine-induced immune thrombotic thrombocytopenia (VITT).2 Here, we identified prothrombotic, platelet-activating anti-PF4 antibodies, not associated with heparin treatment, in a patient with monoclonal gammopathy that resulted in a chronic hypercoagulability state.
Deutsche Forschungsgemeinschaft, grant/award numbers: 374031971-TRR 240 and KFO306.
CommentsThe original article is available at https://haematologica.org/
Published CitationGreinacher A, et al. Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy. Haematologica. 2022;107(5):1219-1221.
Publication Date30 December 2021
- School of Pharmacy and Biomolecular Sciences
PublisherFerrata Storti Foundation
- Published Version (Version of Record)