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Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy

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posted on 15.09.2022, 15:47 authored by Andreas Greinacher, Florian Langer, Linda Schonborn, Thomas Thiele, Munif Haddad, Thomas Renne, Jerome Rollin, Yves Gruel, Theodore E Warkentin

Transient prothrombotic disorders caused by plateletactivating antibodies against platelet factor 4 (PF4) include heparin-induced thrombocytopenia (HIT), spontaneous HIT syndrome,1  and, most recently, vaccine-induced immune thrombotic thrombocytopenia (VITT).2 Here, we identified prothrombotic, platelet-activating anti-PF4 antibodies, not associated with heparin treatment, in a patient with monoclonal gammopathy that resulted in a chronic hypercoagulability state. 

Funding

Deutsche Forschungsgemeinschaft, grant/award numbers: 374031971-TRR 240 and KFO306.

History

Comments

The original article is available at https://haematologica.org/

Published Citation

Greinacher A, et al. Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy. Haematologica. 2022;107(5):1219-1221.

Publication Date

30 December 2021

PubMed ID

34965704

Department/Unit

  • School of Pharmacy and Biomolecular Sciences

Publisher

Ferrata Storti Foundation

Version

  • Published Version (Version of Record)