Platelet mechanosensing as key to understanding platelet function
Purpose of review: This review highlights how the perception of platelet function is evolving based on recent insights into platelet mechanobiology.
Recent findings: The mechanosensitive ion channel Piezo1 mediates activation of free-flowing platelets under conditions of flow acceleration through mechanisms independent of adhesion receptors and classical activation pathways. Interference with the initiation of platelet migration or with the phenotypic switch of migrating platelets to a procoagulant state aggravates inflammatory bleeding. Mechanosensing of biochemical and biophysical microenvironmental cues during thrombus formation feed into platelet contractile force generation. Measurements of single platelet contraction and bulk clot retraction show promise to identify individuals at risk for hemorrhage.
Summary: New findings unravel novel mechanotransduction pathways and effector functions in platelets, establishing mechanobiology as a pivotal component of platelet function. These insights highlight limitations of existing treatments and offer new potential therapeutic approaches and diagnostic avenues based on mechanobiological principles. Further extensive research is required to distinguish between core hemostatic and pathological mechanisms influenced by platelet mechanosensing.
Science Foundation Ireland under the Future Frontiers Programme (19/FFP/6708)
CommentsThis is a pre-copyedited, author-produced version of an article accepted for publication in Current Opinion in Hematology. The published version of record Schoen I, Kenny M, Patil S. Platelet mechanosensing as key to understanding platelet function. Curr Opin Hematol. 2023 is available online at: https://journals.lww.com/co-hematology/abstract/9900/platelet_mechanosensing_as_key_to_understanding.49.aspx https://doi.org/10.1097/moh.0000000000000788
Published CitationSchoen I, Kenny M, Patil S. Platelet mechanosensing as key to understanding platelet function. Curr Opin Hematol. 2023
Publication Date17 October 2023
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
PublisherLippincott Williams And Wilkins
- Accepted Version (Postprint)