Platinum(iv) oxaliplatin-peptide conjugates targeting memHsp70+ p.pdf (768.37 kB)
Download filePlatinum(iv) oxaliplatin-peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells.
journal contribution
posted on 23.11.2019, 11:48 authored by Aoife M. McKeon, Janis Noonan, Marc Devocelle, Brona M. Murphy, Darren M. GriffithNovel Pt(iv) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of metallodrugs to target a membrane bound heat shock protein 70 positive (memHSP70+) phenotype in cancer cells. The conjugates exhibit superior cytotoxicity as compared to oxaliplatin alone in Pt resistant colorectal cancer cells with relatively high memHSP70+ expression. Substitution of TPP in Pt(iv) peptide conjugates with scrambled peptide (ScP) essentially abolishes the observed cytotoxicity.