Royal College of Surgeons in Ireland
Polysaccharide-Based Nanomedicines Targeting Lung Cancer.pdf (2.66 MB)

Polysaccharide-based nanomedicines targeting lung cancer

Download (2.66 MB)
journal contribution
posted on 2023-02-10, 14:15 authored by Asif Ahmad Bhat, Gaurav Gupta, Khalid Saad Alharbi, Obaid Afzal, Abdulmalik S A Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlinRonan MacLoughlin, Brian G Olive, Kamal Dua

A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer is recognised as the most chronic kind of cancer around the globe. Radiation treatment, surgery, and chemotherapy are some medical procedures used in the traditional care of lung cancer. However, these methods lack selectivity and damage nearby healthy cells. Several polysaccharide-based nanomaterials have been created to transport chemotherapeutics to reduce harmful and adverse side effects and improve response during anti-tumour reactions. To address these drawbacks, a class of naturally occurring polymers called polysaccharides have special physical, chemical, and biological characteristics. They can interact with the immune system to induce a better immunological response. Furthermore, because of the flexibility of their structures, it is possible to create multifunctional nanocomposites with excellent stability and bioavailability for the delivery of medicines to tumour tissues. This study seeks to present new views on the use of polysaccharide-based chemotherapeutics and to highlight current developments in polysaccharide-based nanomedicines for lung cancer. 



The original article is available at

Published Citation

Bhat AA. et al. Polysaccharide-based nanomedicines targeting lung cancer. Pharmaceutics. 2022;14(12):2788.

Publication Date

13 December 2022

PubMed ID



  • School of Pharmacy and Biomolecular Sciences




  • Published Version (Version of Record)