Post-COVID-19 human memory impairment: a PRISMA-based systematic review of evidence from brain imaging studies
Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, including memory dysfunction. In this PRISMA-based systematic review, we compared and summarized the current literature looking at the relationship between COVID-19-induced neuropathological changes by neuroimaging scans and memory symptoms experienced by patients who recovered from COVID-19. Overall, this review suggests a correlational trend between structural abnormalities (e.g., cortical atrophy and white matter hyperintensities) or functional abnormalities (e.g., hypometabolism) in a wide range of brain regions (particularly in the frontal, parietal and temporal regions) and memory impairments in COVID-19 survivors, although a causal relationship between them remains elusive in the absence of sufficient caution. Further longitudinal investigations, particularly controlled studies combined with correlational analyses, are needed to provide additional evidence.
CommentsThe original article is available at https://www.frontiersin.org/
Published CitationShan D, et al. Post-COVID-19 human memory impairment: a PRISMA-based systematic review of evidence from brain imaging studies. Front Aging Neurosci. 2022;14:1077384
Publication Date9 December 2022
- Undergraduate Research
PublisherFrontiers Media S.A.
- Published Version (Version of Record)