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Post-translational regulation of the mTORC1 pathway: a switch that regulates metabolism-related gene expression

journal contribution
posted on 2024-03-28, 12:57 authored by Yitao WangYitao Wang, Tobias EngelTobias Engel, Xinchen Teng

The mechanistic target of rapamycin complex 1 (mTORC1) is a kinase complex that plays a crucial role in coordinating cell growth in response to various signals, including amino acids, growth factors, oxygen, and ATP. Activation of mTORC1 promotes cell growth and anabolism, while its suppression leads to catabolism and inhibition of cell growth, enabling cells to withstand nutrient scarcity and stress. Dysregulation of mTORC1 activity is associated with numerous diseases, such as cancer, metabolic disorders, and neurodegenerative conditions. This review focuses on how post-translational modifications, particularly phosphorylation and ubiquitination, modulate mTORC1 signaling pathway and their consequential implications for pathogenesis. Understanding the impact of phosphorylation and ubiquitination on the mTORC1 signaling pathway provides valuable insights into the regulation of cellular growth and potential therapeutic targets for related diseases. 

Funding

National Natural Science Foundation of China (31970550)

Science Foundation Ireland (21/RC/10294_P2)

European Regional Development Fund

FutureNeuro industry partners

History

Comments

The original article is available at https://www.sciencedirect.com/

Published Citation

Wang Y, Engel T, Teng X. Post-translational regulation of the mTORC1 pathway: a switch that regulates metabolism-related gene expression. Biochim Biophys Acta Gene Regul Mech. 2024;1867(1):195005.

Publication Date

18 January 2024

PubMed ID

38242428

Department/Unit

  • Physiology and Medical Physics
  • FutureNeuro Centre

Publisher

Elsevier B.V.

Version

  • Accepted Version (Postprint)