posted on 2021-11-22, 14:09authored byKathleen R Attfield, Wenhao Chen, Kristin J Cummings, Peyton Jacob, Donal O'SheaDonal O'Shea, Jeff Wagner, Ping Wang, Jefferson Fowles
In 2019, the United States
experienced an unprecedented outbreak of electronic cigarette (e-cigarette), or
vaping, product use– associated lung injury (EVALI). Although reports of
lipidladen macrophages in BAL fluid raised the possibility that EVALI
represented exogenous lipoid pneumonia, case series that focused on
histopathology found patterns of acute lung injury, including diffuse alveolar
damage and organizing pneumonia, often with bronchiolitis. Thus, the available evidence to date suggests
the outbreak is characterized by an airway-centered chemical pneumonitis rather
than acute exogenous lipoid pneumonia.
Attfield KR. et al. Potential of ethenone (ketene) to contribute to electronic cigarette, or vaping, product use-associated lung injury. Am J Respir Crit Care Med. 2020;202(8):1187-1189.