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Potentially Inappropriate Prescribing and Potential Prescribing Omissions and ....pdf (217.3 kB)

Potentially inappropriate prescribing and potential prescribing omissions and their association with adverse drug reaction-related hospital admissions.

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Background

This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital.

Methods

Information on medications and morbidities was extracted from the Adverse Drug Reactions in an Ageing Population (ADAPT) cohort (N = 798: N = 361 ADR-related admissions; 437 non-ADR-related admissions). PIP and PPOs were assessed using Beers Criteria 2019 and STOPP/START version 2. Multivariable logistic regression (adjusted odds ratios (aOR), 95%CI) was used to examine the association between PIP, PPOs and ADR-related admissions, adjusting for covariates (age, gender, comorbidity, polypharmacy).

Results

In total, 715 (90%; 95% CI 87-92%) patients had ≥1 Beers Criteria, 555 (70%; 95% CI 66-73%) had ≥ 1 STOPP criteria and 666 patients (83%; 95% CI 81-86%) had ≥ 1 START criteria. Being prescribed at least one Beers (aOR = 1.66, 95% CI = 1.00-2.77), or meeting STOPP (aOR = 1.07, 95% CI = 0.79-1.45) or START (aOR = 0.72; 95%CI = 0.50-1.06) criteria or the number of PIP/PPO criteria met was not significantly associated with ADR-related admissions. Patients prescribed certain drug classes (e.g., antiplatelet agents, diuretics) per individual PIP criteria were more likely to have an ADR-related admission.

Conclusion

There was a high prevalence of PIP and PPOs in this cohort but no association with ADR-related admissions.

Funding

Health Research Board (SDAP-2021-020 and RL-15-1579)

Irish Research Council Government of Ireland Postgraduate ScholarshipProgramme Award (grant number GOIPG/2021/1213)

RCSI StAR MD programme

History

Comments

The original article is available at https://www.mdpi.com/

Published Citation

Brannigan R. et al. Potentially inappropriate prescribing and potential prescribing omissions and their association with adverse drug reaction-related hospital admissions. J Clin Med. 2024;13(2):323.

Publication Date

6 January 2024

PubMed ID

38256457

Department/Unit

  • Beaumont Hospital
  • Data Science Centre
  • General Practice
  • Medicine
  • School of Pharmacy and Biomolecular Sciences
  • Public Health and Epidemiology

Research Area

  • Cancer
  • Vascular Biology
  • Neurological and Psychiatric Disorders
  • Population Health and Health Services

Publisher

MDPI AG

Version

  • Published Version (Version of Record)