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Prasugrel versus ticagrelor for acute coronary syndrome patients undergoing percutaneous coronary intervention: A critical appraisal of randomized controlled trials

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posted on 02.03.2022, 15:37 authored by Talal Almas, Maryam Ehtesham, Janita Basit, Tarek Khedro, Uzair Malik, Vikneswaran Raj Nagarajan, Jung Hur, Norah Alshareef, Areen Fathima, Hafeez Ul Hassan Virk, Aamir HameedAamir Hameed, Jun Li

Every year, millions of coronary stenting procedures are performed for the treatment of ischemic heart disease. Initially, bare metal stents (BMS) were utilized for acute coronary syndromes (ACS) and myocardial infarctions (MIs). While effective, rates of restenosis with BMS were a concern, subsequently leading to the advent of drug-eluting stents (DES). DES were coated with polymers that enabled the slow and controlled release of anti-proliferative agents, such as sirolimus and paclitaxel. Studies thereafter showed that DES indeed led to a marked decrease in the restenosis rate of stented coronary vessels. Nevertheless, despite the plummeting restenosis rates, thrombosis remained an issue, even in DES, where one of the primary concerns was that their non-biodegradable polymers remained after completing drug release. Thereafter, numerous clinical trials and studies have unequivocally demonstrated that treatment with dual antiplatelet therapy (DAPT), a combination of a P2Y12 antagonist and aspirin, is the go-to strategy for these patients.

History

Comments

The original article is available at https://sciencedirect.com/

Published Citation

Almas T. et al. Prasugrel versus ticagrelor for acute coronary syndrome patients undergoing percutaneous coronary intervention: a critical appraisal of randomized controlled trials. Ann Med Surg (Lond). 2022;74:103330

Publication Date

7 February 2022

PubMed ID

35198169

Department/Unit

  • Anatomy and Regenerative Medicine
  • Tissue Engineering Research Group (TERG)
  • Undergraduate Research

Research Area

  • Health Professions Education
  • Biomaterials and Regenerative Medicine
  • Surgical Science and Practice

Publisher

Elsevier BV

Version

  • Published Version (Version of Record)