Pregnancy and delivery in patients with Charcot–Marie–Tooth disease and related disorders.pdf (545.12 kB)
Download file

Pregnancy and delivery in patients with Charcot–Marie–Tooth disease and related disorders

Download (545.12 kB)
journal contribution
posted on 21.09.2022, 08:13 authored by Mariola Skorupinska, Gita Ramdharry, Bridgette ByrneBridgette Byrne, Matilde Laurá, Mary M Reilly

Background Charcot–Marie–Tooth disease is the most common inherited peripheral neuropathy and many patients with Charcot–Marie–Tooth are women of childbearing age. Guidelines for managing pregnancy in Charcot–Marie–Tooth are lacking.

Aims To assess the impact of pregnancy on Charcot–Marie–Tooth and how Charcot–Marie–Tooth affects pregnancy, delivery and postnatal care.

Methods A retrospective questionnaire exploring disease course during pregnancy, delivery, pregnancy complications, anaesthetic management and puerperium was administered to 92 patients with Charcot–Marie–Tooth and related disorders.

Results Worsening of Charcot–Marie–Tooth symptoms were reported in 37% of pregnant patients which resolved after delivery in half of the patients. No significant increase in pregnancy, delivery and anaesthetic complications were observed and the type of delivery did not significantly differ from the normal population.

Conclusions While these results are reassuring, ideally an international prospective study should be done to confirm these results and to develop practice guidelines on the management of pregnancy in Charcot–Marie–Tooth.

Funding

National Institute for Health Research University College London Hospitals Biomedical Research Centre

National Institutes of Neurological Diseases and Stroke and Office of Rare Diseases (U54NS065712)

Medical Research Council (MRC MR/S005021/1)

Muscular Dystrophy Association (MDA510281)

Charcot–Marie–Tooth Association (CMTA)

National Institute for Health Research Clinical Lectureship award (CAT-CL-09-21)

International Centre of Genomic Medicine in Neuromuscular Disorders (ICGNMD, MR/S005021/1)

History

Comments

The original article is available at https://journals.sagepub.com/

Published Citation

Skorupinska M, Ramdharry, Byrne B, Laurá M, Reilly MM. Pregnancy and delivery in patients with Charcot–Marie–Tooth disease and related disorders. Obstet Med. 2022

Publication Date

16 June 2022

Department/Unit

  • Obstetrics and Gynaecology

Publisher

SAGE Publications

Version

  • Published Version (Version of Record)