Prognostic importance of pathological fractures in osteosarcomas
Aims
To investigate whether pathological fractures impact on osteosarcoma patient prognosis in Ireland.
Methods
This was a retrospective study over 22 years in a National Orthopaedic Oncology Centre. There were 117 nonfracture cases and 15 fracture cases. Outcome measures included 5 and 10 year event-free (EFS) and overall survival (OS). Kaplan-Meier curves assessed length of survival and time to death.
Results
Pathological fracture has no significant effect on 10 year EFS or 10 year OS. 3 factors strongly associate with 10 year OS rates: American Joint Committee on Cancer (AJCC) classification (p<0.001), Metastases site (p<0.001) and Distant recurrence (p<0.001). Fractures had poorer post-chemotherapeutic necrosis rates (p=0.005).
Conclusion
Pathological fractures have no significant effect on survival rates or length of survival in an Irish population. The effect of pathological fractures on necrosis rates must be explored in future research.
History
Comments
The original article is available at www.imj.iePublished Citation
Sheridan GA, Mellon L, Thompson EM, O'Kane GM, O'Toole GC. Prognostic Importance of Pathological Fractures in Osteosarcomas. Ir Med J. 2020;112(10):1021.Publication Date
16 December 2020PubMed ID
32311251Department/Unit
- Health Psychology
Publisher
Irish Medical AssociationVersion
- Published Version (Version of Record)