Royal College of Surgeons in Ireland
Browse
Prognostic importance of pathological fractures in osteosarcomas.pdf (725.75 kB)

Prognostic importance of pathological fractures in osteosarcomas

Download (725.75 kB)
journal contribution
posted on 2022-09-01, 11:16 authored by Gerard A Sheridan, Lisa MellonLisa Mellon, E M Thompson, G M O'Kane, G C O'Toole

Aims 

To investigate whether pathological fractures impact on osteosarcoma patient prognosis in Ireland. 

Methods 

This was a retrospective study over 22 years in a National Orthopaedic Oncology Centre. There were 117 nonfracture cases and 15 fracture cases. Outcome measures included 5 and 10 year event-free (EFS) and overall survival (OS). Kaplan-Meier curves assessed length of survival and time to death. 

Results 

Pathological fracture has no significant effect on 10 year EFS or 10 year OS. 3 factors strongly associate with 10 year OS rates: American Joint Committee on Cancer (AJCC) classification (p<0.001), Metastases site (p<0.001) and Distant recurrence (p<0.001). Fractures had poorer post-chemotherapeutic necrosis rates (p=0.005). 

Conclusion 

Pathological fractures have no significant effect on survival rates or length of survival in an Irish population. The effect of pathological fractures on necrosis rates must be explored in future research. 

History

Comments

The original article is available at www.imj.ie

Published Citation

Sheridan GA, Mellon L, Thompson EM, O'Kane GM, O'Toole GC. Prognostic Importance of Pathological Fractures in Osteosarcomas. Ir Med J. 2020;112(10):1021.

Publication Date

16 December 2020

PubMed ID

32311251

Department/Unit

  • Health Psychology

Publisher

Irish Medical Association

Version

  • Published Version (Version of Record)