Royal College of Surgeons in Ireland
Prognostic importance of pathological fractures in osteosarcomas.pdf (725.75 kB)

Prognostic importance of pathological fractures in osteosarcomas

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journal contribution
posted on 2022-09-01, 11:16 authored by Gerard A Sheridan, Lisa MellonLisa Mellon, E M Thompson, G M O'Kane, G C O'Toole


To investigate whether pathological fractures impact on osteosarcoma patient prognosis in Ireland. 


This was a retrospective study over 22 years in a National Orthopaedic Oncology Centre. There were 117 nonfracture cases and 15 fracture cases. Outcome measures included 5 and 10 year event-free (EFS) and overall survival (OS). Kaplan-Meier curves assessed length of survival and time to death. 


Pathological fracture has no significant effect on 10 year EFS or 10 year OS. 3 factors strongly associate with 10 year OS rates: American Joint Committee on Cancer (AJCC) classification (p<0.001), Metastases site (p<0.001) and Distant recurrence (p<0.001). Fractures had poorer post-chemotherapeutic necrosis rates (p=0.005). 


Pathological fractures have no significant effect on survival rates or length of survival in an Irish population. The effect of pathological fractures on necrosis rates must be explored in future research. 



The original article is available at

Published Citation

Sheridan GA, Mellon L, Thompson EM, O'Kane GM, O'Toole GC. Prognostic Importance of Pathological Fractures in Osteosarcomas. Ir Med J. 2020;112(10):1021.

Publication Date

16 December 2020

PubMed ID



  • Health Psychology


Irish Medical Association


  • Published Version (Version of Record)